◆ 研究员
◆ 博士生导师
◆ 基于小分子肽自组装的仿生智能材料
◆ 膜蛋白靶向肽的原位自组装及其在癌症治疗
与再生医学的应用研究
◆ 多靶向纳米药物联合疗法
◆ 南开大学 化学学士
◆ 香港科技大学 化学博士
◆ 2010-2015 美国布兰戴斯大学 材料科学与工程研究中心 博士后
◆ 2015-2022 日本冲绳科技大学院大学 生物模体实验室 准教授/PI
◆ 2022-至今 松山湖材料实验室 智能软物质团队 研究员/PI
课题组网页：www.yezlab.com
课题组的研究工作主要立足于化学生物学(Chemical Biology)的生物材料(Biomaterials)领域。科研实践涉及并交叉合成化学(Synthetic Chemistry), 光化学(Photochemistry), 软物质物理(Soft Matter Physics), 细胞生物学(Cell Biology), 以及生物物理(Biophysics)等多学科。基于力学生物学(Mechanobiology)的生物材料设计与应用开发是本课题组研究工作的特色以及关注重点。
代表性文章
1. Xunwu Hu, Sona Rani Roy, Chengzhi Jin, Guanying Li, Qizheng Zhang, Natsuko Asano, Shunsuke Asahina, Tomoko Kajiwara, Atsushi Takahara, Bolu Feng, Kazuhiro Aoki, Cehnjie Xu, Ye Zhang* “Control Cell Migration by Engineering Integrin Ligand Assembly” Nature Communications, 2022, 13:5002.
2. Jiaqi Song, Qizheng Zhang, Guanying Li,* Ye Zhang* “Constructing ECM-like Structure on the Plasma Membrane via Peptide Assembly to Regulate the Cellular Response”, Langmuir, 2022, 38, 8733-8747.
3. Xunwu Hu, Ye Zhang* “Developing Biomaterials to Mediate the Spatial Distribution of Integrins” Biophysics Reviews, 2021, 2, 041302.
4. Dingze Mang, Sona Rani Roy, Qizheng Zhang, Xunwu Hu, Ye Zhang* “Heparan-Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration” ACS Applied Materials & Interfaces, 2021, 13, 17236-17242.
5. Guanying Li, Xunwu Hu, Xia Wu, Ye Zhang* “Microtubule-Targeted Self-Assembly Triggers Prometaphase-Metaphase Oscillations Suppressing Tumor Growth” Nano Letters, 2021, 21, 3052-3059.
6. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao,* and Ye Zhang* “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-term Lysosome Tracking” Angew. Chem. Int. Ed., 2021, 60, 7597-7601.
7. Guanying Li, Xunwu Hu, Pingping Nie, Dingze Mang, Shi Jiao, Shijin Zhang, Sona Rani Roy, Sachie Yukawa, Shunsuke Asahina, Hiroaki Sugasawa, William Cortes, Zhaocai Zhou* and Ye Zhang* “Lipid-raft-targeted Molecular Self-assembly Inactivates YAP to Suppress Ovarian Cancer Growth” Nano Letters, 2021, 21, 747-755.
8. Xia Wu, Xunwu Hu, Ye Zhang* “Regulate Cellular Responses via Molecular Assembly in Cell Milieu for Cancer Therapy” Chemistry Letters, 2021, 50 (Commemorative Highlight Review), 405-410.
9. Shijin Zhang, and Ye Zhang* “Promote Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly” ACS Applied Materials & Interfaces, 2020, 37, 41105-41112.
10.Sona Rani Roy, Guanying Li, Xunwu Hu, Shijin Zhang, Sachie Yukawa, Enming Du, and Ye Zhang* “Integrin and Heparan Sulfate Dual-targeting Peptide Assembly Suppresses Cancer Metastasis” ACS Applied Materials & Interfaces, 2020, 17, 19277-19284.
11. Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kunichi Miyazawa, and Ye Zhang* "Regulate Higher-order Organization through the Synergy of Two Self-sorted Assemblies" Angew. Chem. Int. Ed. 2018, 57, 3636-3640.
12. Guanying Li, Toshio Sasaki, Shunsuke Asahina, Michael C. Roy, Toshiaki Mochizuki, Koji Koizumi, and Ye Zhang* “Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration” Chem. 2017, 2, 283-298.
13. Qingcong Wei, Mengchi Xu, Chuanan Liao, Qing Wu, Mingyu Liu, Ye Zhang*, Chengtie Wu*, Qigang Wang* "Printable hybrid hydrogel by dual enzymatic polymerization with superactivity" Chemical Science, 2016, 7, 2748.
14. Ye Zhang; Zhou, N.; Shi, J. F.; Pochapsky, S. S.; Pochapsky, T. C.; Zhang, B.; Zhang, X. X.; Xu, B.* “Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” Nature Commun. 2015, 6, 6165.
15. Shi, J. F.; Du, X. W.; Huang, Y. B.; Zhou, J.; Yuan, D.; Wu, D. D.; Ye Zhang; Haburcak, R.; Eptein, I. R.*; Xu, B.* “Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis” J. Am. Chem. Soc. 2015, 137, 26-29.
16. Ye Zhang; Zhou, N.; Kim, D.; Fraden, S.*; Epstein, I. R.*; Xu, B.* “Giant Volume Change of Active Gels under Continuous Flow” J. Am. Chem. Soc., 2014, 136, 7341-7347.
17. Ye Zhang; Zhou, N.; Akella, S.; Kuang, Y.; Kim, D.; Schwartz, A.; Bezpalko, M.; Foxman, B. M.; Fraden, S.; Epstein, I. R.*; Xu, B.* “Active Cross-linkers that Lead to Active Gels” Angew. Chem. Int. Ed. 2013, 52, 6944-6948.
18. Ye Zhang; Zhang, B.; Kuang, Y.; Gao, Y.; Shi, J.; Zhang, X. X.; Xu, B.* “A Redox Responsive, Fluorescent Supramolecular Metallohydrogel Consists of Nanofibers with Single-Molecule Width” J. Am. Chem. Soc., 2013, 135, 5008-5011.
